preparation and quality control of 177lu-chitosan for radiosynovectomy
Authors
abstract
introduction: rheumatoid arthritis (ra) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. radiosynovectomy (rsv) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. several radiopharmaceuticals have been developed for rsv so far, but still development of new radiophamaceuticals is of crucial interest. in this research, the 177lu-chitosan complex (177lu-chito) was introduced as a new agent for rsv. methods: 177lu was produced by irradiation of a natural lu2o3 target at a thermal neutron flux of approximately 4 × 1013 n/cm2·s. 177lu-chito was prepared in the diluted acetic acid solution. the radiochemical yield was checked by itlc method. the biodistribution of the complex was investigated by intra-articular injection to rabbits’ and rats’ knee joints. the leakage of injected dose from the injection site in the rabbit organs was investigated using spect imaging up to 48 hours. results: 177lu was prepared with a specific activity of 2.6-3 gbq.mg-1 and radionuclide purity of 99.98%. 177lu-chito was prepared successfully with high radiochemical purity (95%) and specific activity of 888 tbq/mmol. both the biodistribution data in rats and spect imaging of the rabbit showed that there was no significant leakage of the injected activity even after 192 h. conclusion: considering all of the excellent features of the complex, this radiopharmaceutical can be used for effective management of synovial inflammation.
similar resources
Preparation and quality control of 177Lu-chitosan for radiosynovectomy
Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Se...
full textPreparation and quality control of Lu-chitosan for radiosynovectomy
Introduction: Rheumatoid arthritis (RA) is the most common autoimmune disease, leading to the destruction of the joints and causing pain, disability, and immobility in the patients. Radiosynovectomy (RSV) has been applied as an effective treatment for the patients with resistant synovitis after failure of long-term pharmacotherapy and intra-articular steroid injection for more than 50 years. Se...
full textDevelopment of 177Lu-phytate Complex for Radiosynovectomy
Objective(s): In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. Materials and Methods: Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 1013 n.cm-2.s-1. The product was converted into chloride form which was further used for labeling of 177Lu-phytate complex and che...
full textDevelopment of 177Lu-phytate Complex for Radiosynovectomy
OBJECTIVE(S) In this work a new possible agent for radiosynovectomy has been targeted for articular pain palliation. MATERIALS AND METHODS Lu-177 of 2.6-3 GBq/mg specific activity was obtained by irradiation of natural Lu2O3 sample with thermal neutron flux of 4 × 10(13) n.cm(-2).s(-1). The product was converted into chloride form which was further used for labeling of (177)Lu-phytate complex...
full textDevelopment of Sm-153 chitosan for radiosynovectomy
Introduction: Developing new radiosynovectomy agents is of great importance due to the aging of human populations around the world and increasing the incidence of inflammatory diseases. In this work, Sm-153 chitosan agent was developed for the first time in our country and preparation and quality control of the compound is described. Methods: Sm-153 chloride was ob...
full textProduction and quality control of 166Ho-Chitosan for therapeutic applications
Introduction: In this research, [166Ho]Holmium chitosan complex production is described in details, followed by determination of complex radiochemical purity, stability and biodistribution (after intra-articular injection) in wild-type male rats. Finally a Ho-166 based chitosan kit for ultimate radiosynovectomy as well as radiotherapy applications was developed. Methods: 166</s...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of nuclear medicinePublisher: tehran university of medical sciences
ISSN 1681-2824
volume 22
issue 1 2014
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023